McKesson was not immediately available to comment.
According to settlement papers, McKesson "expressly denies" the government's charges, as well as those of a whistleblower, David Morgan, in a related civil lawsuit filed in New Jersey federal court. The San Francisco-based company did not admit liability or wrongdoing in agreeing to settle.
Fishman said state governments may negotiate separately with McKesson to resolve claims based on their shares of the Medicaid overpayments.
He also said federal and state governments had recovered more than $2 billion from drug companies alleged to have reported inflated pricing information.
Whistleblowers can receive 25 percent of settlement amounts in False Claims Act cases, depending on how much work they contribute.
Neither Morgan nor his lawyer could be immediately located for comment. Morgan filed his lawsuit in 2005, and added McKesson as a defendant in 2006. The case remains under seal.
In morning trading, McKesson shares rose 0.5 percent to $91.83 on the New York Stock Exchange.
The case is U.S. ex rel. Morgan v. Express Scirpts Inc et al, U.S. District Court, District of New Jersey, No. 05-01714.
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