The settlement does not involve any admission of liability by the company and was undertaken to avoid lengthy trials, Glaxo spokeswoman Mary Ann Rhyne said.
In addition to Louisiana, the other states involved are Kentucky, Mississippi, Maryland, South Carolina, New Mexico, West Virginia and Utah.
The news of the Avandia settlement comes at a time when Glaxo is involved in a major investigation by Chinese authorities over allegations of widespread bribery to help sell its medicines in China.
Glaxo last year agreed to pay $3 billion and plead guilty to criminal charges in one of the largest healthcare fraud cases in U.S. history. That case involved marketing of products for unapproved uses, including the antidepressant Paxil to underage patients. That settlement also involved charges of failing to provide the U.S. Food and Drug Administration with Avandia safety data.
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