After losing his proxy battle last year, Icahn said that "activism, especially in biotech, usually takes longer than you believe it will."
At the time, he cited Biogen Idec Inc, where it took Icahn three years to win three seats on the board, and ImClone Systems, where he helped engineer the sale of the company to Eli Lilly & Co.
Morningstar analyst Damien Conover said Forest had several recently launched products and a solid pipeline of drugs in development, making it a potentially attractive target for large drugmakers with a lot of cash and a dearth of new medicines.
" I would think Icahn's motivation here is to get the firm to sell themselves for a premium," Conover said.
Forest's winning slate a year ago included three new board members nominated by the company after Icahn announced his challenge.
Last year's result represented a victory for Forest Chairman and Chief Executive Howard Solomon, who has led the company since 1977.
Forest, which has a market value of about $9 billion, is seeing its profits pressured by patent expirations on its biggest products.
In its most recent quarter, profit plunged 40 percent as the company lost patent protection for its Lexapro antidepressant, ceding sales to low-cost generic versions. Alzheimer's drug Namenda is expected to lose U.S. patent protection in 2015.
Forest has been attempting to build up its product portfolio to make up for the declines of Lexapro and Namenda, including drugs for depression and chronic obstructive pulmonary disease.
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